Diabetes Insipidus: New Concepts for Diagnosis

Diabetes insipidus--diagnosis and management.

Central diabetes insipidus (CDI) is the end result of a number of conditions that affect the hypothalamic-neurohypophyseal system. The known causes include germinoma/craniopharyngioma, Langerhans cell histiocytosis (LCH), local inflammatory, autoimmune or vascular diseases, trauma resulting from surgery or an accident, sarcoidosis, metastases and midline cerebral and cranial malformations. In r...

Diabetes Insipidus: A Challenging Diagnosis with New Drug Therapies

Diabetes Insipidus (DI) is either due to deficient secretion of arginine vasopressin (central) or to tubular unresponsiveness (nephrogenic). Drug induced DI is a well-known entity with an extensive list of medications. Polyuria is generally defined as urine output exceeding 3 liters per day in adults. It is crucial to identify the cause of diabetes insipidus and to implement therapy as early as...

Physiopathology and diagnosis of nephrogenic diabetes insipidus.

Nephrogenic diabetes insipidus (NDI) is caused by an improper response of the kidney to the antidiuretic hormone arginine vasopressin (AVP), leading to a decreased ability to concentrate urine which results in polyuria and polydipsia. The clinical diagnosis of NDI relies on demonstration of subnormal ability to concentrate urine despite the presence of AVP. NDI is most commonly acquired, second...

Diabetes Insipidus

679 W E ARE PRESENTING the case histories of two children with diabetes insipidus, of particular interest because of the diversity of manifestations, the variance in etiology and the complexity of management. One patient was observed for a period of 3 years, with onset of disease at age 10 years; another was observed for a period of 8 years, with the onset of tile primary disease at 2 years and...

Diabetes insipidus.